What Are the Potential Roles of Nuclear Perlecan and Other Heparan Sulphate Proteoglycans in the Normal and Malignant Phenotype

The recent discovery of nuclear and perinuclear perlecan in annulus fibrosus nucleus pulposus cells its known matrix stabilizing properties tissues introduces the possibility that may also have intracellular or regulatory roles through interactions with envelope cytoskeletal proteins nucleosomal-chromatin organization regulate transcriptional factors modulate gene expression. is a mechano-sensor organelle, sophisticated dynamic mechanoresponsive components support protect nucleus, allowing it to perceive respond mechano-stimulation. This review speculates on potential based what already about heparan sulphate proteoglycans. Perlecan frequently found nuclei tumour cells; however, specific role these diseased largely unknown. aim this highlight probable for intriguing interactive proteoglycan normal malignant cell types.